Endocrine Abstracts

Regulation of thyroid hormone (TH) levels in blood is controlled by feedback at the level of the pituitary and hypothalamus. It has been suggested that the set-point of either turning on or off the release of TSH and TRH, respectively is due to multiple factors including intrauterine exposure to TH. We have utilized the TH receptor (TR) β disrupted mouse (TRβ−/−) as model to study the effect of maternal levels of TH on newborn thyroid function. The ration...

T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter-8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compo...

T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter-8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compo...